2. Signaling Pathways
  3. Anti-infection
  4. Reverse Transcriptase

Reverse Transcriptase

Reverse Transcriptase

Related Products

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Reverse transcriptases (RTs) are enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases (RTs) use an RNA template and a short primer complementary to the 3' end of the RNA to direct the synthesis of the first strand cDNA.

Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase. HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.

Reverse Transcriptase Related Products (165):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10574AS
    Rilpivirine-d6 hydrochloride
    Rilpivirine-d6 (hydrochloride) is the deuterium labeled Rilpivirine hydrochloride[1].
    Rilpivirine-d<sub>6</sub> hydrochloride
  • HY-116154
    Metacavir
    		Inhibitor
    Metacavir is an orally active, potent and specific nucleoside reverse transcriptase inhibitor against hepatitis B virus (HBV) with antiviral activity.
    Metacavir
  • HY-10572R
    Efavirenz (Standard)
    		Inhibitor
    Efavirenz (Standard) is the analytical standard of Efavirenz. This product is intended for research and analytical applications. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
    Efavirenz (Standard)
  • HY-118731
    TNK-6123
    		Activator
    TNK-6123 is a potent Emivirine (HY-15353) analogue with improved activity against drug-resistant HIV mutants. TNK-6123 improves activity against Lys103Asn mutant RT.
    TNK-6123
  • HY-17423R
    Abacavir (Standard)
    		Inhibitor
    Abacavir (Standard) is the analytical standard of Abacavir. This product is intended for research and analytical applications. Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity.
    Abacavir (Standard)
  • HY-B0255R
    Adefovir dipivoxil (Standard)
    		Inhibitor
    Adefovir dipivoxil (Standard) is the analytical standard of Adefovir dipivoxil. This product is intended for research and analytical applications. Adefovir dipivoxil, an adenosine analogue, is an oral proagent of the nucleoside reverse transcriptase inhibitor Adefovir. Adefovir dipivoxil inhibits both the wild type and HBV Lamivudine-resistant strains. Adefovir dipivoxil shows anti-orthopoxvirus activity.
    Adefovir dipivoxil (Standard)
  • HY-19111
    R-82150
    		Inhibitor
    R-82150 (TIBO-R 82150) is an HIV-1 reverse transcriptase inhibitor that blocks the reverse transcription of viral RNA by binding to the non-substrate binding site of reverse transcriptase, thereby inhibiting viral replication. R-82150 does not inhibit the replication of HIV-2, other RNA viruses, and DNA viruses.
    R-82150
  • HY-17392R
    Zalcitabine (Standard)
    		Inhibitor
    Zalcitabine (Standard) is the analytical standard of Zalcitabine. This product is intended for research and analytical applications. Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection.
    Zalcitabine (Standard)
  • HY-N7232
    Limocrocin
    		Inhibitor
    Limochromin is a pigment produced by Streptomyces limosus that strongly inhibits the reverse transcriptase of avian myeloid leukemia virus (AMV). The inhibitory activity of limochromin is not affected by changes in the concentration of template-primer, substrate or carrier protein, but its inhibitory effect is significantly reduced when the concentration of AMV reverse transcriptase increases. Limochromin can be used to develop antiviral treatments.
    Limocrocin
  • HY-B0116A
    Stavudine sodium
    		Inhibitor
    Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine sodium induces apoptosis.
    Stavudine sodium
  • HY-16767S1
    Doravirine-13C,d3
    		Inhibitor
    Doravirine-13C,d3 (MK-1439-13C,d3) is the deuterium labeled Doravirine (HY-16767). Doravirine (MK-1439) is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase mutants, respectively.
    Doravirine-<sup>13</sup>C,d<sub>3</sub>
  • HY-169064
    HIV-1 inhibitor-75
    		Inhibitor
    HIV-1 inhibitor-75 is a human immunodeficiency virus 1 (HIV-1) inhibitor, with an EC50 value ranging from 0.0039 to 0.338 μM. The binding target of HIV-1 inhibitor-75 is reverse transcriptase, with an IC50 value of 0.055 μM. HIV-1 inhibitor-75 shows good in vitro metabolic stability, exhibiting moderate clearance rates and a longer half-life in human plasma and liver microsomes.
    HIV-1 inhibitor-75
  • HY-126082
    (+)-Carbovir triphosphate
    		Inhibitor
    (+)-Carbovir triphosphate is an enantiomer of Carbovir triphosphate (HY-131607). (+)-Carbovir triphosphate is an inhibitor and substrate of HIV reverse transcriptase.
    (+)-Carbovir triphosphate
  • HY-107001
    DPC 961
    		Inhibitor
    DPC 961 (DMP 961) is a non-nucleoside reverse transcriptase inhibitor (NNRTI). DPC 961 is a potent and specific inhibitor of HIV-1 reverse transcriptase, which inhibits the activity of HIV-1 reverse transcriptase in a non-competitive manner, thereby preventing viral replication. DPC 961 can be used for research on AIDS.
    DPC 961
  • HY-10570S1
    Nevirapine-d3
    		Inhibitor
    Nevirapine-d3 (BI-RG 587-d3) is the deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1].
    Nevirapine-d<sub>3</sub>
  • HY-117477
    DPC 963
    		Inhibitor
    DPC-963 is an oral active non-nucleoside reverse transcriptase inhibitor with the IC50 of 18 nM. DPC-963 can be used for study of HIV.
    DPC 963
  • HY-122018
    GS-9148
    		Inhibitor
    GS-9148 is a ribose-modified HIV-1 nucleotide reverse transcriptase (RT) inhibitor with an EC50 value of 10.6 µM. GS-9148 shows antiretroviral activity for K65R, L74V, or M184V RT mutation.
    GS-9148
  • HY-10572BS
    (Rac)-Efavirenz-d4
    		Inhibitor
    (Rac)-Efavirenz-d4 is a labelled racemic Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1]. (Rac)-Efavirenz-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (Rac)-Efavirenz-d<sub>4</sub>
  • HY-15232BR
    Tenofovir alafenamide hemifumarate (Standard)
    		Inhibitor
    Tenofovir alafenamide hemifumarate (Standard) is the analytical standard of Tenofovir alafenamide hemifumarate. This product is intended for research and analytical applications. Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
    Tenofovir alafenamide hemifumarate (Standard)
  • HY-13910B
    Tenofovir maleate
    		Inhibitor
    Tenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
    Tenofovir maleate